Christopher M Dobson Selected Research

Clusterin

11/2017	Clusterin protects neurons against intracellular proteotoxicity.
12/2011	The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide.
8/2007	The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures.

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Christopher M Dobson Research Topics

Disease

100	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 04/2002
77	Parkinson Disease (Parkinson's Disease) 04/2024 - 12/2002
76	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2023 - 07/2005
25	Amyloidosis 08/2020 - 04/2002
20	Amyloid Plaque 06/2020 - 12/2002
16	Proteostasis Deficiencies 08/2020 - 08/2009
7	Synucleinopathies 10/2021 - 12/2014
7	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 10/2019 - 01/2012
6	Dementia (Dementias) 01/2021 - 01/2010
5	Neuroblastoma 01/2021 - 01/2017
5	Nervous System Diseases (Neurological Disorders) 01/2021 - 11/2002
4	Huntington Disease (Huntington's Disease) 01/2018 - 12/2003
4	Prion Diseases (Transmissible Spongiform Encephalopathies) 01/2018 - 01/2004
3	Brain Diseases (Brain Disorder) 10/2011 - 04/2002
2	Bacterial Infections (Bacterial Infection) 01/2019 - 01/2009
2	Paralysis (Palsy) 01/2018 - 01/2017
2	Neuroinflammatory Diseases 01/2018 - 01/2013
2	Neoplasms (Cancer) 01/2018 - 01/2009
2	Disease Progression 03/2016 - 12/2014
2	Cataract (Cataracts) 01/2004 - 11/2002
2	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 12/2003 - 12/2002
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2021
1	Multiple System Atrophy 01/2020
1	Muscular Diseases (Myopathy) 12/2019
1	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 10/2019
1	Pre-Eclampsia (Preeclampsia) 01/2019
1	Parkinsonian Disorders (Parkinsonism) 01/2018
1	Type 2 Diabetes Mellitus (MODY) 06/2017
1	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2017
1	Tauopathies 01/2015
1	Neoplasm Metastasis (Metastasis) 06/2014
1	Atherosclerosis 05/2014
1	Arthritis (Polyarthritis) 05/2014

Drug/Important Bio-Agent (IBA)

125	Proteins (Proteins, Gene)FDA Link 01/2023 - 04/2002
113	Amyloid (Amyloid Fibrils)IBA 04/2024 - 04/2002
67	Peptides (Polypeptides)IBA 01/2021 - 12/2002
63	SynucleinsIBA 04/2024 - 09/2010
18	Muramidase (Lysozyme)IBA 11/2017 - 08/2003
14	alpha-SynucleinIBA 03/2016 - 01/2005
12	Intrinsically Disordered ProteinsIBA 01/2018 - 01/2005
9	Amyloid beta-PeptidesIBA 01/2019 - 10/2008
8	Protein AggregatesIBA 12/2019 - 10/2015
7	LipidsIBA 01/2021 - 01/2017
7	Molecular Chaperones (Chaperone, Molecular)IBA 01/2021 - 10/2011
5	SolutionsIBA 11/2020 - 09/2005
4	Crystallins (Crystallin)IBA 01/2021 - 01/2004
4	PrionsIBA 01/2021 - 10/2015
4	polyglutamineIBA 01/2018 - 11/2014
3	CalciumIBA 01/2021 - 03/2006
3	Small Heat-Shock ProteinsIBA 01/2021 - 03/2010
3	Single-Domain AntibodiesIBA 01/2021 - 10/2013
3	DNA-Binding Proteins (DNA Binding Protein)IBA 10/2019 - 01/2016
3	AntibodiesIBA 01/2019 - 01/2017
3	ClusterinIBA 11/2017 - 08/2007
2	Prion ProteinsIBA 01/2021 - 12/2003
2	Amino Acids FDA Link 01/2021 - 07/2014
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 03/2016
2	24-dihydroxy-5-cholestane 24-sulfate 3-N-1(spermine)-7IBA 01/2020 - 01/2018
2	Cytotoxins (Cytolysins)IBA 01/2020 - 01/2019
2	UbiquitinIBA 10/2019 - 11/2017
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2019 - 05/2014
2	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2018 - 11/2017
2	Protein Isoforms (Isoforms)IBA 01/2016 - 11/2015
2	lacmoidIBA 01/2012 - 09/2009
2	Phospholipids (Phosphatides)FDA LinkGeneric 02/2010 - 07/2009
2	Congo RedIBA 09/2009 - 12/2003
1	AMPA Receptors (AMPA Receptor)IBA 01/2021
1	N-Methylaspartate (NMDA)IBA 01/2021
1	peptide AIBA 01/2021
1	NeurotoxinsIBA 11/2020
1	Lipid Bilayers (Lipid Bilayer)IBA 10/2020
1	Cystatin CIBA 08/2020
1	Cyclic PeptidesIBA 10/2019
1	Coloring Agents (Dyes)IBA 10/2019
1	Cysteine (L-Cysteine)FDA Link 08/2019
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2019
1	Fluorescent Dyes (Fluorescent Probes)IBA 12/2018
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2018
1	glucose-regulated proteinsIBA 01/2018
1	CholesterolIBA 01/2018
1	DipeptidesIBA 11/2017
1	tau Proteins (tau Protein)IBA 11/2017
1	squalamineIBA 01/2017
1	Inosine Diphosphate (IDP)IBA 05/2016
1	MetalsIBA 03/2016
1	IonsIBA 03/2016
1	Bexarotene (LGD1069)FDA Link 02/2016
1	Indicators and Reagents (Reagents)IBA 01/2016
1	Huntingtin ProteinIBA 06/2015
1	Chemokine CX3CL1IBA 01/2015
1	Cell Surface ReceptorsIBA 11/2014
1	Hypochlorous Acid (Hypochlorite)IBA 05/2014
1	SulfonamidesIBA 01/2014
1	Immunoglobulin FragmentsIBA 10/2013
1	SeleniumIBA 06/2012
1	RibonucleoproteinsIBA 01/2012
1	Heterogeneous-Nuclear Ribonucleoproteins (Informatin)IBA 01/2012
1	Apolipoprotein A-I (Apolipoprotein A1)IBA 04/2011

Therapy/Procedure

6	Therapeutics 10/2021 - 03/2003
2	Immunotherapy 01/2017 - 12/2014